Somatic Cell Dedifferentiation: Rendering Ethically Controversial Therapeutic Cloning Obsolete?

Ever since the debate of embryo-destructive stem-cell research began in earnest in 1998 when researchers at the University of Wisconsin first isolated human embryonic stem cells, we’ve known that the best overall answer to the ethical impasse would be a solution that both allows the search for stem-cell related cures to go foreword, while doing so without harming or destroying embryonic human life in the process.

We now have that solution.

Two major scientific papers published today in Science and Cell offer proof of principle research to show that it is possible to generate patient-matched pluripotent stem cells without human cloning and its attendant moral pitfalls: the need to harvest and use human eggs from female donors and the subsequent destruction of cloned human embryos. Both studies used reprogramming of adult human cells to generate stem cells known as “induced pluripotent state cells” (iPSCs) that have all the properties of human embryonic stem cells.